Calendario

Noviembre 2017
LunMarMierJueVierSabDom
 << < > >>
  12345
6789101112
13141516171819
20212223242526
27282930   

Anuncio

¿Quién está en línea?

Miembro: 0
Visitante: 1

rss Sindicación

Selecting Entities on Sites and Performing Tasks On Them Through Google

Visitors to a website may want to perform certain actions related to Entities (specific places or people or things) that are displayed to them on the Web.

For example, at a page for a restaurant (an entity), a person viewing the site may want to create a reservation or get driving directions to the restaurant from their current location. Doing those things may require a person to take a number of steps, such as selecting the name of the restaurant and copying it, pasting that information into a search box, and submitting it as a search query, selecting the site from search results, determining if making a reservation is possible on the site, and then providing information necessary to make a reservation; getting driving directions may also require multiple steps.

Using a touch screen device may potentially be even more difficult because the site would possibly then be limited to touch input.

A patent granted to Google this week describes a way to easily identify an entity such as a restaurant on a touch device, and select it online and take some action associated with that entity based upon the context of a site the entity is found upon. Actions such as booking a reservation at a restaurant found on a website, or procuring driving directions to that site, or other actions could be easily selected by the user of a site.

The patent is:

Semantic selection and purpose facilitation

Inventors: Paul Nordstrom, Casey Stuart Whitelaw,

Assignee: Google

US Patent 9,305,108

Granted April 5, 2016

Filed: October 5, 2012

Abstract

Computer-implemented methods for proposing actions to a user to select based on the users predicted purpose for selecting content are provided. In one aspect, a method includes receiving an identifier of a referent entity associated with user-selectable content, identifying, based on a prediction of a purpose in selecting the content, at least one action to be executed that is associated with the entity, and providing, for display, at least one identifier of the at least one action to the device for selection by a user. Systems, graphical user interfaces, and machine-readable media are also provided.

How an entity and actions might be selected by a site visitor

A person searches for a site using text such as sushi restaurants in Mountain View. That person then circles the text we love Ramen Sushi out of all of the places weve been to on the web page they found with that search, by circling the text using a touch input. Based on the content they chose and the context of their selection of that text, The system decides that viewer of the page has selected Ramen Sushi, and it proposes that entity to the user. The user can confirm that, and is then given a number of actions to perform on the entity based on a context of that selection.

Someone circles an entity on a touch screen to perform actions on it.Someone circles an entity on a touch screen to perform actions on it.

The context can include:

The current location of the deviceA past location of the deviceThe type of the device A previous action associated with the entity taken by the user or another userA search queryInformation on another user associated with the userThe file from which the user-selectable content was selectedThe remaining content from which the user-selectable content was selected

Actions might then be displayed that could include:

Directions to Ramen SushiMake a reservation at Ramen SushiOperating hours for Ramen Sushi Reviews of Ramen Sushi

Once an action is chosen, it can be performed by the system.

Entities are contained in an entity database, which may contain attributes or properties associated with the entity, and those can be pre-defined, and can have associated descriptors such as location, restaurant, and phone number. An entity that is a person such as George Washington can have an associated descriptor notable person.

The patent tells us that entities that are listed in the entity database can be associated with one or many user purposes and/or actions based on an associated descriptor.

A purpose is something that a user would want to do or find out with respect to an entity that selected. These actions are shown in a menu to the user as choices of actions to take regarding selected entities. These purposes may be referred to as a task. The patent provides a number of examples, that include:

play (e.g. for games and sports), rate or evaluate, travel to, contact, communicate, share, record, remember, dine, consume, experience or enjoy (e.g. art, music), reserve (tickets, etc.), compare, learn, study, understand, purchase, repair, fix, teach, cook, and make. For the example purpose dine, an example sub-purpose can be eat dinner, from which example sub-purposes can be make reservation, get directions, and find parking.

The patent tells us that users can select multiple entities of the same type at the same time to compare them.

Entities, purposes, and actions can be added to the entity database either manually or automatically with a user (or even an owner of the entity) adding information. The patent provides some examples of how information might be added to the entity database, but it seems to be fairly wide open under the patent.

The patent doesnt mention Schema vocabulary, which would be one way for a site owner to add entity information to an entity database.

Entities may be products, and actions presented to a user could include providing a review of the product, identifying a seller of the product, providing a price for the product, or providing an offer (e.g., discount or coupon) associated with the product. If the entity is a service, such as watching a movie or a plumber for hire, the actions that may be presented to the user could include providing a review of the service, identifying an availability of the service (e.g., show times), identifying a location where the service is being provided (e.g., an address of the plumber), or providing an option to purchase the service (e.g., purchasing tickets for the movie or rates offered by the plumber).

Take Aways

The entity database described in this patent could be a very big one, containing multiple businesses (like those from Google Maps), multiple products, multiple people (like those found at a knowledge base like Wikipedia), and multiple potential actions and tasks associated with those entities.

This seems to be a fairly aspirational patent, which might require a lot of steps being put into place before it is implemented. It does present a vision of how entities on the web could eventually be acted upon by people who see them in web pages.

This could be something that Google may intend to do, and some of the pieces for it are in place, such as a knowledge graph filled with entities, and a schema system that is extendable. Its interesting seeing a patent that lays out a framework like this one does. Is this a future path that Google will follow? We may need to wait to see.

Shares 345

http://feedproxy.google.com/~r/seobythesea/Tesr/~3/9ujomMm8fKY/
22 Avr 2016

Google Assigns 148 Medical Patents to Verily Life Sciences

verily logo

Back in September of 2009, I wrote a blog post that I titled Googles 10 Oddest Patents. The first of those that I included in that list was one named Instrument for medical purposes, I included it mostly because Google was a search company, and it felt odd that Google would have a patent on a medical process. That one used ultrasonic sound to investigate the structural makeup of biological tissue in organs and vessels.

Times have changed, and since that time, Google has restructured and put itself under a holding company structure with the name Alphabet running all elements of the company. A branch of the Company had evolved that was being referred to as Google Life Sciences, and it changed names recently as well, to Verily Life Sciences.

What role and what kind of impact might these new subsidiary have? I was wondering if Google would make changes to the patent assignments it had made along with the name changes, and I was surprised to see them do so, where they assigned 148 patents to Verily Life Sciences on two different days. Its an interesting list, and Ive provided it here. They may technically have ownership under other patents as well, but this list points to a number that could possibly become products that the company offers to the public, after any government approval that they may need to pursue.

This recent story highlights the kind of approval that medical devices need to acquire before they are used for medical purposes: Google offshoot Verily reveals connectivity device to aggregate medical data.

Verily may become involved in medical studies, like this one described to be between Vanderbilt and Verily: Vanderbilt, Googles Verily to Launch Precision Medicine Initiative Cohort.

This article provides some possible valuations as to what kinds of money are potentially available to companies providing healthcare products and benefits to people: How Alphabet Is Eyeing The Lucrative Healthcare Industry With Verily.

This article presents healthcare as a potentially very lucrative field for Google to be entering: New Miniature Continuous Glucose Monitoring Devices from DexCom and Verily (Google Life Sciences) Promise to Make Glucose Monitoring Wearable and Affordable.

This followup to that story shows that plans are being made to release products over the next few years: Googles Verily, Dexcom aim to launch mini glucose monitor in 2018, with next-gen by 2021.

Ive written about one of these patents in the past, in the post Google Files Patent For Wearable Nanotechnology Anti-Cancer Technology, and that patent is included in the assignment, as is a patent for a Star Trek like Needle free blood draw device that was published this past December.

I decided to publish links to these patent filings, and information about the dates they were filed, and when they were either published (for the pending patent applications) or granted (for the many that have been granted so far). There are many contact lens focused patents in the group, but other ones that have different purposes as well. If any stand out to you as interesting in some way, please share with us, and let us know why.

There seem to be many opportunities available to Google to pursue, and Im excited that so many options are open to them. I also like that now that Im seeing patents that describe medical devices coming from Google, that enough has changed that I no longer think of them as odd, but am instead excited to see how those may be used. These are exciting times, and it appears that Google is off to a good start addressing medical problems.

Contact Lenses

Inventors: Brian Otis, Babak Amirparviz

Filed Jul 10, 2014

Granted Aug 5, 2014

Abstract:

Apparatus, systems and methods for facilitating iris-scanning contact lenses and/or biometric identification employing iris scanning contact lenses are provided. In one implementation, the contact lens can include: a transparent substrate formed to cover at least a portion of an iris of an eye; and a circuit. The circuit can include: one or more light sensors disposed on or within the transparent substrate and that detects light filtered through the iris and incident on the one or more light sensors; readout circuitry, operably coupled to the one or more light sensors, that outputs information indicative of the light filtered through the iris and incident on the one or more light sensors; and a power component that supplies power to the readout circuitry. In various implementations, the contact lens can be employed in systems and/or methods associated with authentication and identification.

Contact Lenses With Hybrid Power Sources

Inventors: Nathan Pletcher, Brian Otis

Filed Jul 26, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods of contact lenses with power sources are provided. In some aspects, a contact lens can include a substrate; and a circuit. The circuit can include: one or more sensors disposed on or within the substrate; circuitry disposed on at least a portion of the substrate; one or more photovoltaic cells disposed on at least a portion of the substrate; and a hybrid power component that supplies at least one of two or more different types of power to the circuitry, wherein at least one of the two or more different types of power is radio frequency/inductive power. In various aspects, other types of power can be solar and/or microelectromechanical system power. Additionally, in various aspects, photovoltaic cells can be arrayed in different configurations and/or over a significant portion of a viewing surface of the contact lens. In some aspects, the photovoltaic cells can be transparent.

Contact Lens Employing Optical Signals for Power and/or Communication

Inventors: Nathan Pletcher, Brian Otis

Filed Jul 26, 2012

Granted Oct 13, 2015

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate that forms at least a portion of the body of the contact lens; an optical communication device disposed on or within the substrate; and a photodetector disposed on or within the substrate, wherein the photodetector harvests light emitted from a device and generates power from the harvested light. In some aspects, an apparatus comprises a tag having a circuit including: an optical communication device; and a photodetector that harvests light received and generates power from the harvested light. The tag can be disposed on or within a contact lens in various aspects.

Actuatable Contact Lenses

Inventors: Harvey Ho

Filed Aug 2, 2012

Granted Dec 30, 2014

Abstract:

Apparatus, systems and methods for facilitating actuatable contact lenses are provided. In one aspect, the contact lens can include: a substrate comprised of a material that is actuatable to at least one of change a base curvature from a first curvature to a second curvature or change a thickness from a first thickness to a second thickness; and a control component, operably coupled to the material, that outputs actuation information to cause the material to actuate and at least one of change the base curvature of the material or change the thickness of the material. The contact lens can be actuated based on a condition associated with an environment surrounding the contact lens, a sensed prescription for an eye over which the contact lens is placed or based on a focal point of the eye. The material can include piezoelectric film, a shape memory alloy, hydrogel and/or silicone elastomer.

Contact Lenses Having Two-Electrode Electrochemical Sensors

Inventors: Zenghe Liu

Filed Aug 6, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

Contact Lens with Integrated Pulse Oximeter

Inventors: Harvey Ho, Babak Amirparviz

Filed Aug 21, 2012

Granted Mar 3, 2015

Abstract:

Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.

Passive Surface Acostic Wave Communication

Inventors: Harvey Ho, Babak Amirparviz

Filed Sep 5, 2012

Granted Sep 2, 2014

Abstract:

This disclosure relates to systems and/or methods for detection of eye blinking by interrogating a passive surface acoustic wave based contact lens using an interrogation signal and interpreting reflections of the interrogation signal from the passive surface acoustic wave based contact lens.

In-Situ Tear Sample Collection and Testing Using a Contact Lens

Inventors: Zenghe Liu, James Etzkorn

Filed Sep 7, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Sensor

Inventors: Zenghe Liu, Babak Amirparviz

Filed Sep 17, 2012

Published Jul 24, 2014

Abstract:

Apparatus, systems and methods employing contact lenses having an electrochemical sensor to detect ethanol concentration of a wearer of the contact lens are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and an electrochemical sensor, disposed on or within the substrate, that detects information related to concentration of alcohol present in blood of a wearer of the contact lens.

Contact Lens that Facilitates Antenna Communication Via Sensor Impedance Modulation

Inventors: Brian Otis, Nathan Pletcher

Filed Sep 24, 2012

Granted Oct 28, 2014

Abstract:

Systems, contact lenses and methods that facilitate antenna communication via sensor impedance modulation are provided. In one aspect, a system can include a contact lens and a radio frequency (RF) reader. The contact lens can include a substrate; an RF antenna, disposed on or within the substrate; and a sensing component, disposed on or within the substrate, and directly coupled to the RF antenna, wherein the RF antenna is configured to change impedance value as a sensed value of the sensing component changes. The RF reader is external to the contact lens, and configured to interrogate the RF antenna with an RF signal. The RF reader can receive a reflected RF signal from the RF antenna in response to the interrogation. The magnitude, phase and/or a frequency of the reflected RF signal can be based on the impedance value of the RF antenna.

Contact Lens That Restricts Incoming Light To The Eye

Inventors: James Etzkorn, Brian Otis

Filed Sep 24, 2012

Granted Feb 24, 2015

Abstract:

This disclosure generally relates to systems and/or methods to restrict light entering an opening of an eye pupil by detecting pupil dilation, detecting incoming light intensity or direction, and adjusting light restricting properties of one or more light restricting regions of the contact lens based upon the detected pupil dilation parameters and incoming light intensity or direction.

Information Processing Method

Inventors: Ehsan Saeedi, Babak Amirparviz

Filed Sep 25, 2012

Published Mar 27, 2014

Abstract:

Systems, apparatus and methods including a contact lens that facilitates collection and/or processing of information associated with sensed features are provided. In one aspect, a system can include a contact lens and an analysis component external to the contact lens. The contact lens can include: a substrate; and a circuit, disposed on or within the substrate. The circuit can include: a plurality of sensors configured to sense respective features associated with a wearer of the contact lens; and a communication component configured to communicate information indicative of sensed features. The analysis component can be configured to: receive the information indicative of the sensed features; and generate statistical information based, at least, on the information indicative of the sensed features.

Facilitation of Temperature Compensation For Contact Lens Sensors and Temperature Sensing

Inventors: Zenghe Liu, Nathan Pletcher, Brian Otis

Filed Sep 25, 2012

Published Mar 17, 2015

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.

Contact Lens Having a Chip Integrated Into a Polymer Substrate and Method of Manufacture

Inventors: James Etzkorn

Filed Sep 25, 2012

Published Mar 27, 2014

Abstract:

Contact lenses and methods of manufacture are provided. In one aspect, a method includes: positioning components in predefined locations on a first surface; applying pressure on the components employing a second surface; providing molten material between the first surface and the second surface and around the components; embedding the components in a substrate by cooling the molten material and causing the molten material to harden, the substrate being a substantially solid form of molten material; and removing the first surface and the second surface after embedding the components in the substrate. The method can also include: providing, on or within a contact lens, one of the components and the substrate into which the component is embedded. The first surface can include molds sized to receive and maintain the components at the predefined locations. The first surface and/or the second surface can be pre-treated with a non-stick coating such as Polytetrafluoroethylene.

Wearable Device

Inventors: Babak Amirparviz, Harvey Ho

Filed Sep 25, 2012

Granted Mar 24, 2015

Abstract:

Apparatus, systems and methods employing a contact lens that generates information indicative of a hydration level of an eye in which the lens is worn, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a hydration component that generates information associated with a hydration level of an eye in which the contact lens is worn.

Assembling Thin Silicon Chips on a Contact Lens

Inventors: James Etzkorn

Filed Sep 26, 2012

Granted Feb 24, 2015

Abstract:

A contact lens having a thin silicon chip integrated therein is provided along with methods for assembling the silicon chip within the contact lens. In an aspect, a method includes creating a plurality of lens contact pads on a lens substrate and creating a plurality of chip contact pads on a chip. The method further involves applying assembly bonding material to the each of the plurality of lens contact pads or chip contact pads, aligning the plurality of lens contact pads with the plurality of chip contact pads, bonding the chip to the lens substrate via the assembly bonding material using flip chip bonding, and forming a contact lens with the lens substrate.

Contact Lens Having an Uneven Embedded Substrate and Method of Manufacture

Inventors: James Etzkorn, Babak Amirparviz

Filed Sep 26, 2012

Granted Mar 24, 2015

Abstract:

Contact lenses and methods of manufacturing contact lenses are provided. In one aspect, a method includes: forming a substrate having an uneven surface; providing a sensor at a first region of the substrate; providing a chip at a second region of the substrate; and encapsulating the substrate, sensor and chip in a polymer. The method also includes: patterning interconnections from the first region of the substrate to the second region of the substrate; and patterning metal pads proximate to the second region of the substrate. The chip can be provided on a metal pad. The uneven surface can be a sloped surface or one or more sloped channels in the substrate, and the channels can be wide enough to receive interconnections for the chip and to receive the chip. Further, the substrate can be ring-shaped and curved prior to encapsulation.

In-Vitro Contact Lens Testing

Inventors: Zenghe Liu, James Etzkorn

Filed Sep 26, 2012

Granted Sep 2, 2014

Abstract:

Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

Facilitation of Tear Sample Collection and Testing Using a Contact Lens

Inventors: James Etzkorn, Zenghe Liu

Filed Sep 26, 2012

Published Mar 27, 2014

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.

Image Capture Component on Active Lens

Inventors: Nathan Pletcher, Olivia Hatalsky, Babak Amirparviz

Filed Oct 8, 2012

Published Apr 10, 2014

Abstract:

This disclosure relates to systems and/or methods for capturing image data representing a scene in a gaze of a viewer via a thin image capture component integrated on or within a contact lens, processing the image data, and employing the processed image data to perform functions locally on the contact lens or remotely on one or more remote devices.

In-vitro Calibration Of An Ophthalmic Analyte Sensor

Inventors: Brian Otis, Zenghe Liu

Filed Oct 12, 2012

Published Apr 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

Contact Lens and Method of Manufacture to Improve Sensor Sensitivity

Inventors: Jeffrey George Linhardt, James Etzkorn

Filed Oct 24, 2012

Granted Nov 3, 2015

Abstract:

Contact lenses and methods of manufacture are provided. A contact lens can include: an electronics substrate having components formed thereon and disposed within a contact lens forming (CLF) polymer, wherein a first one of the components is positioned at a first region of the electronics substrate and a second one of the components is positioned at a second region of the electronics substrate, the second region being opposite the first region; and a plurality of CLF polymer layers molded such that the plurality of CLF polymer layers has a first thickness in a region of the electronics substrate associated with the first one of the components and has a second thickness in a region of the electronics substrate associated with the second one of the components.

Encapsulated Electronics

Inventors: James Etzkorn, Babak Amirparviz

Filed Jan 15, 2013

Granted Oct 28, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.

Method of Ring-Shaped Structure Placement in an Eye-Mountable Device

Inventors: Jeffrey George Linhardt, Harvey Ho

Filed Jan 17, 2013

Published Jul 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement

Inventors: Nathan Pletcher, Brian Otis

Filed Jan 25, 2013

Published Jul 31, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Mar 26, 2013

Granted Oct 20, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure has a first side defined by a first layer of bio-compatible material, a second side defined by a second layer of bio-compatible material, an electronic component, and a conductive pattern that defines sensor electrodes. A portion of the second layer of bio-compatible material is removed by etching to create at least one opening in the second side in which the sensor electrodes are exposed. The etching further removes a portion of the first layer of bio-compatible material so as to create at least one opening in the first side that is connected to the at least opening in the second side. With this arrangement of openings, analytes can reach the sensor electrodes from either the first side or the second side of the bio-compatible structure.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Mar 27, 2013

Granted Aug 25, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Utilizing Oscillator Frequency Divider Settings As A Temperature Sensor In Radio Frequency Applications

Inventors: Brian Patrick Otis, Nathan Pletcher, Daniel Yeager

Filed May 24, 2013

Granted May 5, 2015

Abstract:

Methods and systems for utilizing oscillator frequency divider settings as a temperature sensor are described herein. An example method may involve a reader device transmitting an RF signal to a tag device that includes an electronic oscillator configured to generate an oscillator signal with an oscillator frequency and a frequency adjuster configured to adjust the oscillator frequency with a frequency adjustment factor to provide a resulting frequency, the oscillator frequency being dependent on a temperature of the tag device and the resulting frequency being based on a reference frequency provided by the RF signal. The method may also involve the reader device receiving data from the tag device, the data being indicative of the oscillator frequency. The method may further involve the reader device determining an estimate of the temperature of the tag device based on at least the received data and a predetermined relationship between temperature and oscillator frequency.

Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device

Inventors: James Etzkorn, Stephen ODriscoll

Filed Jun 14, 2013

Published Dec 18, 2014

Abstract:

Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Physiological Measurement Using Wearable Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published Dec 25, 2014

Abstract:

A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface. The device may also include a signal source configured to transmit an interrogating signal into the portion of subsurface vasculature, thereby generating a response signal in response to the interrogating signal.

Test Platform for Wrist-Mounted Physiologic Measurement Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published Dec 25, 2014

Abstract:

A test model has an outer polymer layer that models an exterior surface of a human arm and includes at least a wrist portion, an inner polymer core that is at least partially surrounded by the outer polymer layer and extends into the wrist portion, and polymer tubing adjacent to the inner polymer core. The polymer tubing is at least partially surrounded by the outer polymer layer and extends into the wrist portion. The polymer tubing has a first fluid inlet and a first fluid outlet. The test model is substantially free of metallic and magnetic materials.

Physiological Measurement Using Wearable Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published 20140378777

Dec 25, 2014

Abstract:

A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Container

Inventors: Jeffrey George Linhardt, Daniel Barrows

Filed Jun 24, 2013

Granted Jun 2, 2015

Abstract:

The present disclosure provides an apparatus including a first chamber containing an eye-mountable device. The apparatus may also include a second chamber containing an aqueous solution. The apparatus may also include a membrane positioned between the first chamber and the second chamber. The membrane may be configured to rupture based on application of a force to the apparatus. The ruptured membrane may allow the aqueous solution to engage with the eye-mountable device. The apparatus may also include a lid to seal one or more of the first chamber and the second chamber.

Device Identification

Inventors: Daniel Yeager, Brian Otis, Andrew Nelson

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An eye-mountable device includes a controller embedded in a polymeric material configured for mounting to a surface of an eye. The controller is electrically connected to an antenna included in the eye-mountable device. The controller is configured to: (i) receive an indication of an interrogation signal via the antenna, (ii) responsive to the interrogation signal, output a substantially unique identification sequence; and (iii) use the antenna to communicate the substantially unique identification sequence. The substantially unique identification sequence can then be used by external readers to associate the eye-mountable device with device-specific information without storing such information on the eye-mountable device.

Methods for Adhering a Substrate to a Polymer Layer

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring-shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.

Chemically Reactive Enzyme Immobilization

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains having covalent bonds to an analyte sensing component. The method includes combining the precursor components of the sensing layer, depositing the combined mixture on a surface of an electrode, and curing the deposited mixture.

Porous Polymeric Formulation Prepared Using Monomer

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks.

Porous Polymeric Formulation Prepared Using Porogens

Inventors: Jeffrey George Linhardt, Zenghe Liu, Huanfen Yao

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.

Enzyme Immobilization by Crosslinking

Inventors: Zenghe Liu

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes an electrode, a sensing layer in contact with a surface of the electrode, and a protective membrane. The sensing layer is a crosslinked, hydrophilic copolymer including poly(alkylene oxide) and poly(vinyl pyridine), and an analyte sensing component is immobilized within the crosslinked, hydrophilic copolymer. The protective membrane is a crosslinked, hydrophilic copolymer including alkylene oxide, vinyl pyridine and styrene units. The method involves the formation of a sensing layer on a surface of an electrode, followed by the formation of a protective membrane on a surface of the sensing layer.

Methods for Forming a Channel Through a Polymer Layer Using One or More Photoresist Layers

Inventors: Huanfen Yao, Babak Parviz, Jeffrey George Linhardt

Filed Jun 28, 2013

Granted May 12, 2015

Abstract:

A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.

Devices and Methods for a Contact lens with an Outward Facing Light Source

Inventors: Brian Otis, Robert Francis Wiser, Andrew Nelson

Filed Jun 28, 2013

Granted Sep 16, 2014

Abstract:

A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.

Devices and Methods for a Contact lens with an Inward Facing Light SourceE

Inventors: Brian Otis, William James Biederman

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An eye-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a concave surface and a convex surface, with the concave surface configured to removably mount the eye-mountable device on a corneal surface overlaying a pupil. A light source can be disposed on the substrate and configured to emit light through the concave surface and towards the corneal surface such that the emitted light is viewable through the pupil. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to modulate the light emitted by the light source to provide modulated light.

Reader Communication with Contact Lens Sensors and Display Device

Inventors: Frank Honor, Andrew Nelson, Brian Otis

Filed Jun 28, 2013

Granted Dec 30, 2014

Abstract:

A reader for communicating with both an eye-mountable device and a display device is provided. The reader can transmit radio frequency power to a tag that is part of the eye-mountable device. The reader can communicates with the tag using a first protocol. Communicating with the tag can include having the reader request data from the tag and receive the requested data from the tag. The reader can process the received data. The reader can store the processed data. The reader can communicates with the display device using a second protocol, where the first and second protocols can differ. Communicating with the display device can include having the reader transmit the stored data to the display device. The display device can receive the transmitted data, process the transmitted data, and generate one or more displays including the transmitted and/or processed data.

Using Unique Identifiers to Retrieve Configuration Data for Tag Devices

Inventors: Alice Lin, Andrew Nelson, Daniel Yeager, Brian Otis

Filed Aug 22, 2013

Granted Feb 2, 2016

Abstract:

Methods and systems for using unique identifiers to retrieve configuration data for tag devices are described herein. An example method may involve obtaining a unique identifier associated with a tag device. The tag device may include an antenna and a sensor configured to obtain sensor readings that can be wirelessly transmitted to a reader device via the antenna. The method may also involve determining configuration parameters associated with the tag device based on the unique identifier. The method may further involve storing, in at least one memory, at least a portion of the configuration parameters in association with the unique identifier.

Sacrificial Layers for Bio-Compatible Devices

Inventors: James Etzkorn, Harvey Ho, Huanfen Yao

Filed Aug 27, 2013

Published Mar 5, 2015

Abstract:

A method may involve: forming a sacrificial layer on a working substrate; forming a first bio-compatible layer on the sacrificial layer such that the first bio-compatible layer adheres to the sacrificial layer; forming a conductive pattern on the first bio-compatible layer; mounting an electronic component to the conductive pattern; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, and the conductive pattern; and removing the sacrificial layer to release the bio-compatible device from the working substrate. The first bio-compatible layer defines a first side of a bio-compatible device. The second bio-compatible layer defines a second side of the bio-compatible device.

Nanoparticle Phoresis

Inventors: Andrew Jason Conrad

Filed Sep 5, 2013

Published Mar 5, 2015

Abstract:

Functionalized particles in the blood are able to selectively bind to targets in the blood that have adverse health effects. The binding of the particles to the targets allows the targets to be selectively modified or destroyed by energy from outside the body such that the adverse health effects are reduced or eliminated. The energy is generated by a wearable device which is able to direct the energy into the subsurface vasculature of the wearer of the wearable device. Further, one or more of the functionalized particles may be magnetic, allowing a magnetic field generated by the wearable device and directed into the subsurface vasculature to concentrate the bound targets in a lumen of the subsurface vasculature proximate to the wearable device.

Delivery of Functionalized Particles

Inventors: Andrew Jason Conrad

Filed Sep 5, 2013

Published Mar 5, 2015

Abstract:

A device includes a capsule sized to pass through a lumen of a gastrointestinal tract, a plurality of functionalized particles disposed within the capsule, one or more tissue penetrating members configured to puncture a wall of the lumen of the intestinal tract; and an actuator having a first configuration and a second configuration. The actuator is configured to retain the plurality of functionalized particles within the capsule in the first configuration. The actuator is further configured to advance the plurality of functionalized particles from the capsule into a wall of the lumen of the gastrointestinal tract via the one or more tissue penetrating members by the actuator transitioning from the first configuration to the second configuration. Systems including the device and methods of delivering functionalized particles to the body are also provided.

Assembling Thin Silicon Chips on a Contact Lens

Inventors: James Etzkorn

Filed Sep 12, 2013

Granted Jun 9, 2015

Abstract:

A contact lens having a thin silicon chip integrated therein is provided along with methods for assembling the silicon chip within the contact lens. In an aspect, a method includes creating a plurality of lens contact pads on a lens substrate and creating a plurality of chip contact pads on a chip. The method further involves applying assembly bonding material to the each of the plurality of lens contact pads or chip contact pads, aligning the plurality of lens contact pads with the plurality of chip contact pads, bonding the chip to the lens substrate via the assembly bonding material using flip chip bonding, and forming a contact lens with the lens substrate.

Devices and Methods for a Contact lens with an Outward Facing Light Source

Inventors: Brian Otis, Robert Francis Wiser, Andrew Nelson

Filed Sep 16, 2013

Granted Sep 9, 2014

Abstract:

A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.

Devices and Methods for a Contact lens with an Inward Facing Light Source

Inventors: Brian Otis, William James Biederman

Filed Sep 16, 2013

Granted Jul 1, 2014

Abstract:

An eye-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a concave surface and a convex surface, with the concave surface configured to removably mount the eye-mountable device on a corneal surface overlaying a pupil. A light source can be disposed on the substrate and configured to emit light through the concave surface and towards the corneal surface such that the emitted light is viewable through the pupil. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to modulate the light emitted by the light source to provide modulated light.

Reader Communication With Contact Lens Sensors and Display Device

Inventors: Brian Otis, Frank Honor, Andrew Nelson

Filed Sep 16, 2013

Granted Sep 8, 2015

Abstract:

A reader for communicating with both an eye-mountable device and a display device is provided. The reader can transmit radio frequency power to a tag that is part of the eye-mountable device. The reader can communicates with the tag using a first protocol. Communicating with the tag can include having the reader request data from the tag and receive the requested data from the tag. The reader can process the received data. The reader can store the processed data. The reader can communicates with the display device using a second protocol, where the first and second protocols can differ. Communicating with the display device can include having the reader transmit the stored data to the display device. The display device can receive the transmitted data, process the transmitted data, and generate one or more displays including the transmitted and/or processed data.

Device With Dual Power Sources

Inventors: Nathan Pletcher, Daniel Yeager, William James Biederman, Andrew Nelson

Filed Sep 16, 2013

Granted Jun 3, 2014

Abstract:

A wearable device includes a sensor, auxiliary electronics, a primary power supply configured to harvest radio frequency (RF) radiation received from an external reader and use the harvested RF radiation to power the sensor, and an auxiliary power supply configured to harvest energy other than that received from the external reader and use the harvested energy to supply power to the sensor and/or the auxiliary electronics. The external reader may supply less power in response to operation of the auxiliary power supply. Additionally or alternatively, in response to a determination that the auxiliary power supply is unable to supply power, the wearable device may disable all auxiliary electronics but for the sensor. In response to a determination that the primary power supply is unable to supply power but the auxiliary power supply is able to supply power, the wearable device may retain operating parameters in the memory storage unit using the auxiliary power supply.

Contact Lenses Having Two-Electrode Electrochemical Sensors

Inventors: Zenghe Liu

Filed Sep 17, 2013

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

Contact Lens with Integrated Pulse Oximeter

Inventors: Harvey Ho, Babak Amirparviz

Filed Sep 17, 2013

Granted Dec 9, 2014

Abstract:

Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.

In-vitro Calibration Of An Ophthalmic Analyte Sensor

Inventors: Brian Otis, Zenghe Liu

Filed Sep 19, 2013

Published Apr 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

Encapulated Electronics

Inventors: James Etzkorn, Babak Amirparviz

Filed Sep 19, 2013

Granted Nov 11, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.

Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement

Inventors: Nathan Pletcher, Brian Otis

Filed Sep 20, 2013

Granted Jan 6, 2015

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Sep 20, 2013

Granted Feb 10, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Sep 23, 2013

Granted Apr 21, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Device Having Embedded Antenna

Inventors: James Etzkorn, Stephen ODriscoll

Filed Sep 24, 2013

Published Dec 18, 2014

Abstract:

Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Information Processing Method

Inventors: Ehsan Saeedi, Babak Amirparviz

Filed Sep 24, 2013

Published Mar 27, 2014

Abstract:

Systems, apparatus and methods including a contact lens that facilitates collection and/or processing of information associated with sensed features are provided. In one aspect, a system can include a contact lens and an analysis component external to the contact lens. The contact lens can include: a substrate; and a circuit, disposed on or within the substrate. The circuit can include: a plurality of sensors configured to sense respective features associated with a wearer of the contact lens; and a communication component configured to communicate information indicative of sensed features. The analysis component can be configured to: receive the information indicative of the sensed features; and generate statistical information based, at least, on the information indicative of the sensed features.

Container

Inventors: Jeffrey George Linhardt, Daniel Barrows

Filed Sep 24, 2013

Granted Nov 11, 2014

Abstract:

The present disclosure provides an apparatus including a first chamber containing an eye-mountable device. The apparatus may also include a second chamber containing an aqueous solution. The apparatus may also include a membrane positioned between the first chamber and the second chamber. The membrane may be configured to rupture based on application of a force to the apparatus. The ruptured membrane may allow the aqueous solution to engage with the eye-mountable device. The apparatus may also include a lid to seal one or more of the first chamber and the second chamber.

Method And System For Measuring Pyruvate

Inventors: Huanfen Yao, Zenghe Liu

Filed Oct 17, 2013

Granted Aug 4, 2015

Abstract:

A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Method And System For Measuring Urea

Inventors: Huanfen Yao, Zenghe Liu

Filed Oct 17, 2013

Published Apr 23, 2015

Abstract:

A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.

Modulation of a Response Signal to Distinguish Between Analyte and Background Signals

Inventors: Jason Thompson, Andrew Conrad, Eric Peeters, Vikram Singh Bajaj, Mark Askew

Filed Oct 23, 2013

Published Apr 23, 2015

Abstract:

A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background.
21 Avr 2016
Admin · 17 vistas · Escribir un comentario

Computational Queries: The New Vista in Search

Computational queries have emerged as a new category of search behavior. The most common type of computational query I use is how far from HERE to THERE. Sometimes I do this when driving around town. Sometimes I do this when helping someone plan a road trip. Some times I do this when I read an interesting article about astronomy.

Another type of computational query is how long does it take to bake cookies? There are differences in baking times. Unlike the distance-based computational queries baking-based computational queries require additional explicit criteria from the user (unless they are willing to settle for random information).

Both types of computational queries rely upon what I shall call Responsive Contexts: the additional information returned or required for resolving the query correctly changes based on circumstance.

In a distance-based query the additional information may include road closings and openings, traffic accidents, time of day (allowing for rush hour), and congestion due to construction projects and other factors (such as politicalmotorcades). The search engine or app may or may not have this information when you run the query.

In a baking-based query the additional information may include size of oven, type of oven, ingredients used in the recipe, and desired texture of the food. There is less information volatility in a baking query unless you have to pay attention to altitude, outside temperature, humidity, and things like that (and, yes, there are cooking articles to go into these kinds of details).

The simple query how long does it take to boil a pot of water also has Responsive Contexts. A few years ago it was deemed sufficient to give a single, simple example. Now people are modifying their queries to look for answers based on their elevations above sea-level, and maybe also based on their source of heat. General search and app search may not see enough volume in these types of queries to anticipate this kind of computation.

Youll know the search volume is sufficient when you start to see answers in the search results or apps that take your location and elevation into consideration when you type in how long to boil water. If you just searched on different types of pots, maybe a smart query resolver will take the different materials into consideration. If it knows you are in the middle of a national forest a smart app should anticipate that you are using sterno and a camping stove.

As Web marketers we dont yet have enough data about everything to speak in broad terms of Responsive Context but we are moving in that direction. I see this happening in site search more and more often. Site search drives more than 70% of all Web search (far more than Google). I suspect the percentage is even higher in app-based site search. But we dont bake Responsive Contextualization into our site search tools very often.

One way to do this is to allow the searcher to configure persistent filters rather than force them to re-enter those filters on every search. Another way to do this is to take whatever is in the users shopping cart into consideration. If I just puta camping tent in my shopping cart maybe when I search for chair, bench, table, or stool I am looking for more camping gear. Unfortunately the major retail sites dont yet give us this kind of smart search, but they will. They already suggest additional products based on what we have carted or purchased.

It happens in all kinds of ecommerce. If you register a domain name you are inundated with additional deals for HTTPS certificates, privacy services, Web hosting, etc. Merchants even offer you discounts on additional purchases. But they have not yet contextualized their site search tools to take these recent transactions into consideration.

If you are just blogging you can create Responsive Contexts by subdividing your articles to cover the different contexts. Its a bit like creating three images of different sizes to be used in a Responsive Ad unit. The search engine, seeing the very different contextual information, pulls the best matching information from your article to satisfy the query.

I have created Responsive Contexts in articles but its not easy to do. You can use tabular data layouts, structured markup, and sometimes just well-highlighted paragraphs of text (use bold and italics to call out important facts, not keywords). A good example of where youre likely to find Responsive Contexts in structured markup is customer reviews on sites like Yelp and TripAdvisor. By slightly changing the query you can get to different reviews or comments on the same business listings; ideally, we want the search engines to take notice of where we are and what we are doing to help us drill down to the correct comments or reviews, although that wont always be computationally possible.

To feed the right answers to the Computational Queries you have to define the problem in such a way that the search engine or app sees the relevance to the query. You must then provide contexts for the answers you include. And you cannot possibly anticipate all the possible contexts that people will need to qualify their answers.

But assuming we can incorporate Responsive Contextualization into our editorial policies, how should we measure placement, visibility, off-site conversion, and insight conversion? We dont have proper tools for doing this.

Well probably have to invent new types of meta markup that can be tracked. I hate the idea of pumping more analytics code into Web pages but marketers want to know what the ROI is. If you are contemplating developing Responsive Contexts for 100,000 items in your query base you had better know what that will cost and have a projection for what kind of revenue will come back from the effort. Hence, you need to run experiments and without good analytics markup you wont have good experimental data.

Click-tracking is our best opportunity for measuring Responsive Contextualization. This may lead to problems down the road. Well be designing things like intrapage doorway widgets that are used to measure performance based on context.



But standards for measuring Ad Viewability may help us solve that sticky problem. If the context is viewed and an encoded action is performed then maybe we wont have to resort to in-page illusions (that search engines will almost certainly object to) in order to capture user activity data. The data will become vital to next generation on-page optimization because today we dont measure intrapage performance even though the search engines have been displaying random sections of pages in the SERPs for years.

Marketers have yet to let go of their outdated ideas about pages and (queries, keywords, or topics). It is not that the page is relevant to some query, it is that only some portionof the page is relevant to the query. This is an important concept that people need to understand. A few years ago in an article titled These Arent the Meta Descriptions Youre OptimizingFor I wrote that the whole page is the meta description. I warned readers then that I would say very little about this for a few years. That is because by ignoring meta descriptions and focusing on putting indexable text on the page that targets many queries you gain a competitive advantage over other people who are still fussing with meta descriptions.

You should assume that the meta description tag is as dead, useless, and irrelevant to search engine optimization as the keywords meta tag. Your natural instinct will be to argue the point, which just holds you back. Stop and think about which helps you more:

A search engine displays a text snippet from a meta descriptionA search engine displays the same text snippet from on the page

The second situation gives you a relevance boost for the query. The first situation provides nothing toward computing the IR score that helps your page rank for the query in the first place.

Worse, most marketers think about meta descriptions the wrong way anyway. They choose the best possible meta description for a single query and limit the amount of text (usually to about 25 words); instead, you should be including meta text that addresses multiple queries, up to 250 words.

But you can and should be putting those 250 words on the page so they help with your optimization. And since the search engines will grab those words anyway, you dont need meta descriptions. You have not needed meta descriptions for at least five years. Worse, you have been DE-optimizing your pages by trying to craft ideal meta descriptions that favored one query over many others.

The age of Computational Queries and Responsive Contexts may finally help marketers abandon meta descriptions and other outdated practices. The idea of optimizing for topics wont fit into this model, although many people will try to say its the same thing. A topic has no context and therefore cannot be responsive to a computational query.

But not everything will become a computational query, either. Can I paint my car is a very different query from how much paint do I need for a 2001 Toyota Corolla? You may see the same results for these two queries, especially if you have been searching on topics related to 2001 Toyota Corolla. But the answers you need are very different. For example, some communities may forbid people from painting their own cars. That is a context you wont include in your question although you may search for it later (or before you get to can I paint my car?).

Related queries reveal more about the context to the search engine but are hidden from the marketer. The searcher may want to know things like:

How to paint a carCan I paint my own car in [LOCATION]Cost to paint a carHow much paint for a [CAR MODEL]Tools for painting your own car

Where in that sequence do you fit? The search engine may help you appear in queries for people who want to legally paint their own Ford Probe in their home town assuming you are relevant to that context, and you may not appear anywhere in a query related to a community across the country. You wont know the search context for the query that brought the visitor to your site. And that same visitor may run other queries after visiting your site to fill out their knowledge about how to do the project.

This is not a traditional local search query, but its a localized computational query. Apple, Bing, and Google are laying the groundwork for resolving these kinds of queries but their solutions are, I think, still years in the future.

What the search engines want to do is see that the searcher is trying to paint their car. They might develop algorithms that assemble the whole plan for the searcher. Such results would look very different from what we see in the SERPs today. For example, the searcher might see:

A local government site with regulations about painting your carA local paint store with the type of paint you needA local hardware store with the tools you needA how to guide with pictures and/or video showing you how to do itExamples of people who painted their own cars (maybe blog posts)

And then you would see normal (lacking context) search results for whatever the last query was. We could call this a Search Results Plan. Does it sound too far-fetched? We already see ads for related services based on these kinds of queries. The organic results are far less organized. When organic catches up to paid search in this area marketers will scramble to create proper contextual clues in their content to help resolve these kinds of queries.

Stop obsessing over data science and artificial intelligence. Its not all about how the search engines implement data analysis and AI decision-making algorithms. They have to have good data to work with. The marketers who get on top of the contextualization issue will be the ones who succeed in the next generation of search optimization strategies.

As search engines become better at interpreting searcher intentions and move away from their current (and very horrible) one solution fits all methods for generating search results they should create new marketing opportunities for Website owners who just want to participate in queries. Although search results exclusion will increase the diversification in searcher contexts should lead to more smaller sites earning traffic because they will better fit the needs of individual searchers than the larger, by-the-data Websites that continue to chase keywords.

Youll see yet more calls for brand-focused optimization in this new universe of search. Brand-based optimization will never go away but it is a terribly crude strategy for meeting tomorrows search needs. SEO sophistication has to look down the road far enough to have the pieces in place so that the search engines can evaluate the new data structures (not structured markup) and informational components so that they can develop the algorithms to make better use of the information they are indexing and sharing with searchers.

This is one area where publishers must be the innovators. In five years you can look back at this article and say with all the smugness you can muster, Well, he got THIS PART wrong but you probably wont even be involved in Web marketing if you dont start evolving now.

Share on LinkedInShare on reddit


http://www.seo-theory.com/2016/01/19/computational-queries-the-new-vista-in-search/
21 Avr 2016
Admin · 12 vistas · Escribir un comentario

Hitting the reset button on your perspective

I find that most people, including myself, struggle with perspective. What I mean is that while most of us know whats most important in life and have a general sense of thankfulness, we often stray from those grounding principles for one reason or another.

Or as Paul Simon once sang, Time passes. A mind wonders. It seems mindless, but it does.

Mind you,there are a variety of ways to keep that stream of consciousness flowing in a generally happy and serene direction, both at work and at play. For me, it usually comes from diving deep into the meaning and general theme of songs like the Grateful Deads Black Peter or an obvious personal favorite like Lightnin Hopkins Going Away:

Theres also a quasi-mathematical process that I often engage in particularly within the bounds of my marketing work that seems to pay huge dividends in terms of keeping my perspective set to the right angle. It basically entails stepping out from the moment as if it where a point on a three-dimensional graph, and pulling up and out a few orders of magnitude so that I can peer into the situation Im facing from the standpoint of a month, year, or even decade.

I cant tell you how many times this has saved me from snapping on a colleague, creating a fire drill for direct reports, making a rash decision without enough data or strategic thinking, or even walking away from a generally fantastic gig based on what amounts to a few hours of stress or uncertainty.

And while eachof these approaches to serenity work well for me as well as various others such as trading in superstition in exchange for skepticism Im fairly sure that by far the best technique is to simply give to others.

Give your work mates a compliment or a gift (or even just a round of beers). Give your loved ones a hug and an I love you. Give an underprivileged kid a guitar.

Just give. Its like a compass for your perspective.

http://www.hugoguzman.com/2014/05/hitting-the-reset-button-on-your-perspective/
20 Avr 2016
Admin · 12 vistas · Escribir un comentario

Google Assigns 148 Medical Patents to Verily Life Sciences

verily logo

Back in September of 2009, I wrote a blog post that I titled Googles 10 Oddest Patents. The first of those that I included in that list was one named Instrument for medical purposes, I included it mostly because Google was a search company, and it felt odd that Google would have a patent on a medical process. That one used ultrasonic sound to investigate the structural makeup of biological tissue in organs and vessels.

Times have changed, and since that time, Google has restructured and put itself under a holding company structure with the name Alphabet running all elements of the company. A branch of the Company had evolved that was being referred to as Google Life Sciences, and it changed names recently as well, to Verily Life Sciences.

What role and what kind of impact might these new subsidiary have? I was wondering if Google would make changes to the patent assignments it had made along with the name changes, and I was surprised to see them do so, where they assigned 148 patents to Verily Life Sciences on two different days. Its an interesting list, and Ive provided it here. They may technically have ownership under other patents as well, but this list points to a number that could possibly become products that the company offers to the public, after any government approval that they may need to pursue.

This recent story highlights the kind of approval that medical devices need to acquire before they are used for medical purposes: Google offshoot Verily reveals connectivity device to aggregate medical data.

Verily may become involved in medical studies, like this one described to be between Vanderbilt and Verily: Vanderbilt, Googles Verily to Launch Precision Medicine Initiative Cohort.

This article provides some possible valuations as to what kinds of money are potentially available to companies providing healthcare products and benefits to people: How Alphabet Is Eyeing The Lucrative Healthcare Industry With Verily.

This article presents healthcare as a potentially very lucrative field for Google to be entering: New Miniature Continuous Glucose Monitoring Devices from DexCom and Verily (Google Life Sciences) Promise to Make Glucose Monitoring Wearable and Affordable.

This followup to that story shows that plans are being made to release products over the next few years: Googles Verily, Dexcom aim to launch mini glucose monitor in 2018, with next-gen by 2021.

Ive written about one of these patents in the past, in the post Google Files Patent For Wearable Nanotechnology Anti-Cancer Technology, and that patent is included in the assignment, as is a patent for a Star Trek like Needle free blood draw device that was published this past December.

I decided to publish links to these patent filings, and information about the dates they were filed, and when they were either published (for the pending patent applications) or granted (for the many that have been granted so far). There are many contact lens focused patents in the group, but other ones that have different purposes as well. If any stand out to you as interesting in some way, please share with us, and let us know why.

There seem to be many opportunities available to Google to pursue, and Im excited that so many options are open to them. I also like that now that Im seeing patents that describe medical devices coming from Google, that enough has changed that I no longer think of them as odd, but am instead excited to see how those may be used. These are exciting times, and it appears that Google is off to a good start addressing medical problems.

Contact Lenses

Inventors: Brian Otis, Babak Amirparviz

Filed Jul 10, 2014

Granted Aug 5, 2014

Abstract:

Apparatus, systems and methods for facilitating iris-scanning contact lenses and/or biometric identification employing iris scanning contact lenses are provided. In one implementation, the contact lens can include: a transparent substrate formed to cover at least a portion of an iris of an eye; and a circuit. The circuit can include: one or more light sensors disposed on or within the transparent substrate and that detects light filtered through the iris and incident on the one or more light sensors; readout circuitry, operably coupled to the one or more light sensors, that outputs information indicative of the light filtered through the iris and incident on the one or more light sensors; and a power component that supplies power to the readout circuitry. In various implementations, the contact lens can be employed in systems and/or methods associated with authentication and identification.

Contact Lenses With Hybrid Power Sources

Inventors: Nathan Pletcher, Brian Otis

Filed Jul 26, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods of contact lenses with power sources are provided. In some aspects, a contact lens can include a substrate; and a circuit. The circuit can include: one or more sensors disposed on or within the substrate; circuitry disposed on at least a portion of the substrate; one or more photovoltaic cells disposed on at least a portion of the substrate; and a hybrid power component that supplies at least one of two or more different types of power to the circuitry, wherein at least one of the two or more different types of power is radio frequency/inductive power. In various aspects, other types of power can be solar and/or microelectromechanical system power. Additionally, in various aspects, photovoltaic cells can be arrayed in different configurations and/or over a significant portion of a viewing surface of the contact lens. In some aspects, the photovoltaic cells can be transparent.

Contact Lens Employing Optical Signals for Power and/or Communication

Inventors: Nathan Pletcher, Brian Otis

Filed Jul 26, 2012

Granted Oct 13, 2015

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate that forms at least a portion of the body of the contact lens; an optical communication device disposed on or within the substrate; and a photodetector disposed on or within the substrate, wherein the photodetector harvests light emitted from a device and generates power from the harvested light. In some aspects, an apparatus comprises a tag having a circuit including: an optical communication device; and a photodetector that harvests light received and generates power from the harvested light. The tag can be disposed on or within a contact lens in various aspects.

Actuatable Contact Lenses

Inventors: Harvey Ho

Filed Aug 2, 2012

Granted Dec 30, 2014

Abstract:

Apparatus, systems and methods for facilitating actuatable contact lenses are provided. In one aspect, the contact lens can include: a substrate comprised of a material that is actuatable to at least one of change a base curvature from a first curvature to a second curvature or change a thickness from a first thickness to a second thickness; and a control component, operably coupled to the material, that outputs actuation information to cause the material to actuate and at least one of change the base curvature of the material or change the thickness of the material. The contact lens can be actuated based on a condition associated with an environment surrounding the contact lens, a sensed prescription for an eye over which the contact lens is placed or based on a focal point of the eye. The material can include piezoelectric film, a shape memory alloy, hydrogel and/or silicone elastomer.

Contact Lenses Having Two-Electrode Electrochemical Sensors

Inventors: Zenghe Liu

Filed Aug 6, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

Contact Lens with Integrated Pulse Oximeter

Inventors: Harvey Ho, Babak Amirparviz

Filed Aug 21, 2012

Granted Mar 3, 2015

Abstract:

Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.

Passive Surface Acostic Wave Communication

Inventors: Harvey Ho, Babak Amirparviz

Filed Sep 5, 2012

Granted Sep 2, 2014

Abstract:

This disclosure relates to systems and/or methods for detection of eye blinking by interrogating a passive surface acoustic wave based contact lens using an interrogation signal and interpreting reflections of the interrogation signal from the passive surface acoustic wave based contact lens.

In-Situ Tear Sample Collection and Testing Using a Contact Lens

Inventors: Zenghe Liu, James Etzkorn

Filed Sep 7, 2012

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses having one or more sensor that sense an analyte in tear fluid and one or more recesses that collect the tear fluid. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a recess formed within the substrate configured to collect tear fluid when the contact lens is worn. The contact lens further includes at least one sensor disposed within the substrate configured to sense presence of an analyte in the collected tear fluid.

Sensor

Inventors: Zenghe Liu, Babak Amirparviz

Filed Sep 17, 2012

Published Jul 24, 2014

Abstract:

Apparatus, systems and methods employing contact lenses having an electrochemical sensor to detect ethanol concentration of a wearer of the contact lens are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and an electrochemical sensor, disposed on or within the substrate, that detects information related to concentration of alcohol present in blood of a wearer of the contact lens.

Contact Lens that Facilitates Antenna Communication Via Sensor Impedance Modulation

Inventors: Brian Otis, Nathan Pletcher

Filed Sep 24, 2012

Granted Oct 28, 2014

Abstract:

Systems, contact lenses and methods that facilitate antenna communication via sensor impedance modulation are provided. In one aspect, a system can include a contact lens and a radio frequency (RF) reader. The contact lens can include a substrate; an RF antenna, disposed on or within the substrate; and a sensing component, disposed on or within the substrate, and directly coupled to the RF antenna, wherein the RF antenna is configured to change impedance value as a sensed value of the sensing component changes. The RF reader is external to the contact lens, and configured to interrogate the RF antenna with an RF signal. The RF reader can receive a reflected RF signal from the RF antenna in response to the interrogation. The magnitude, phase and/or a frequency of the reflected RF signal can be based on the impedance value of the RF antenna.

Contact Lens That Restricts Incoming Light To The Eye

Inventors: James Etzkorn, Brian Otis

Filed Sep 24, 2012

Granted Feb 24, 2015

Abstract:

This disclosure generally relates to systems and/or methods to restrict light entering an opening of an eye pupil by detecting pupil dilation, detecting incoming light intensity or direction, and adjusting light restricting properties of one or more light restricting regions of the contact lens based upon the detected pupil dilation parameters and incoming light intensity or direction.

Information Processing Method

Inventors: Ehsan Saeedi, Babak Amirparviz

Filed Sep 25, 2012

Published Mar 27, 2014

Abstract:

Systems, apparatus and methods including a contact lens that facilitates collection and/or processing of information associated with sensed features are provided. In one aspect, a system can include a contact lens and an analysis component external to the contact lens. The contact lens can include: a substrate; and a circuit, disposed on or within the substrate. The circuit can include: a plurality of sensors configured to sense respective features associated with a wearer of the contact lens; and a communication component configured to communicate information indicative of sensed features. The analysis component can be configured to: receive the information indicative of the sensed features; and generate statistical information based, at least, on the information indicative of the sensed features.

Facilitation of Temperature Compensation For Contact Lens Sensors and Temperature Sensing

Inventors: Zenghe Liu, Nathan Pletcher, Brian Otis

Filed Sep 25, 2012

Published Mar 17, 2015

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.

Contact Lens Having a Chip Integrated Into a Polymer Substrate and Method of Manufacture

Inventors: James Etzkorn

Filed Sep 25, 2012

Published Mar 27, 2014

Abstract:

Contact lenses and methods of manufacture are provided. In one aspect, a method includes: positioning components in predefined locations on a first surface; applying pressure on the components employing a second surface; providing molten material between the first surface and the second surface and around the components; embedding the components in a substrate by cooling the molten material and causing the molten material to harden, the substrate being a substantially solid form of molten material; and removing the first surface and the second surface after embedding the components in the substrate. The method can also include: providing, on or within a contact lens, one of the components and the substrate into which the component is embedded. The first surface can include molds sized to receive and maintain the components at the predefined locations. The first surface and/or the second surface can be pre-treated with a non-stick coating such as Polytetrafluoroethylene.

Wearable Device

Inventors: Babak Amirparviz, Harvey Ho

Filed Sep 25, 2012

Granted Mar 24, 2015

Abstract:

Apparatus, systems and methods employing a contact lens that generates information indicative of a hydration level of an eye in which the lens is worn, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a hydration component that generates information associated with a hydration level of an eye in which the contact lens is worn.

Assembling Thin Silicon Chips on a Contact Lens

Inventors: James Etzkorn

Filed Sep 26, 2012

Granted Feb 24, 2015

Abstract:

A contact lens having a thin silicon chip integrated therein is provided along with methods for assembling the silicon chip within the contact lens. In an aspect, a method includes creating a plurality of lens contact pads on a lens substrate and creating a plurality of chip contact pads on a chip. The method further involves applying assembly bonding material to the each of the plurality of lens contact pads or chip contact pads, aligning the plurality of lens contact pads with the plurality of chip contact pads, bonding the chip to the lens substrate via the assembly bonding material using flip chip bonding, and forming a contact lens with the lens substrate.

Contact Lens Having an Uneven Embedded Substrate and Method of Manufacture

Inventors: James Etzkorn, Babak Amirparviz

Filed Sep 26, 2012

Granted Mar 24, 2015

Abstract:

Contact lenses and methods of manufacturing contact lenses are provided. In one aspect, a method includes: forming a substrate having an uneven surface; providing a sensor at a first region of the substrate; providing a chip at a second region of the substrate; and encapsulating the substrate, sensor and chip in a polymer. The method also includes: patterning interconnections from the first region of the substrate to the second region of the substrate; and patterning metal pads proximate to the second region of the substrate. The chip can be provided on a metal pad. The uneven surface can be a sloped surface or one or more sloped channels in the substrate, and the channels can be wide enough to receive interconnections for the chip and to receive the chip. Further, the substrate can be ring-shaped and curved prior to encapsulation.

In-Vitro Contact Lens Testing

Inventors: Zenghe Liu, James Etzkorn

Filed Sep 26, 2012

Granted Sep 2, 2014

Abstract:

Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

Facilitation of Tear Sample Collection and Testing Using a Contact Lens

Inventors: James Etzkorn, Zenghe Liu

Filed Sep 26, 2012

Published Mar 27, 2014

Abstract:

Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.

Image Capture Component on Active Lens

Inventors: Nathan Pletcher, Olivia Hatalsky, Babak Amirparviz

Filed Oct 8, 2012

Published Apr 10, 2014

Abstract:

This disclosure relates to systems and/or methods for capturing image data representing a scene in a gaze of a viewer via a thin image capture component integrated on or within a contact lens, processing the image data, and employing the processed image data to perform functions locally on the contact lens or remotely on one or more remote devices.

In-vitro Calibration Of An Ophthalmic Analyte Sensor

Inventors: Brian Otis, Zenghe Liu

Filed Oct 12, 2012

Published Apr 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

Contact Lens and Method of Manufacture to Improve Sensor Sensitivity

Inventors: Jeffrey George Linhardt, James Etzkorn

Filed Oct 24, 2012

Granted Nov 3, 2015

Abstract:

Contact lenses and methods of manufacture are provided. A contact lens can include: an electronics substrate having components formed thereon and disposed within a contact lens forming (CLF) polymer, wherein a first one of the components is positioned at a first region of the electronics substrate and a second one of the components is positioned at a second region of the electronics substrate, the second region being opposite the first region; and a plurality of CLF polymer layers molded such that the plurality of CLF polymer layers has a first thickness in a region of the electronics substrate associated with the first one of the components and has a second thickness in a region of the electronics substrate associated with the second one of the components.

Encapsulated Electronics

Inventors: James Etzkorn, Babak Amirparviz

Filed Jan 15, 2013

Granted Oct 28, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.

Method of Ring-Shaped Structure Placement in an Eye-Mountable Device

Inventors: Jeffrey George Linhardt, Harvey Ho

Filed Jan 17, 2013

Published Jul 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement

Inventors: Nathan Pletcher, Brian Otis

Filed Jan 25, 2013

Published Jul 31, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Mar 26, 2013

Granted Oct 20, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure has a first side defined by a first layer of bio-compatible material, a second side defined by a second layer of bio-compatible material, an electronic component, and a conductive pattern that defines sensor electrodes. A portion of the second layer of bio-compatible material is removed by etching to create at least one opening in the second side in which the sensor electrodes are exposed. The etching further removes a portion of the first layer of bio-compatible material so as to create at least one opening in the first side that is connected to the at least opening in the second side. With this arrangement of openings, analytes can reach the sensor electrodes from either the first side or the second side of the bio-compatible structure.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Mar 27, 2013

Granted Aug 25, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Utilizing Oscillator Frequency Divider Settings As A Temperature Sensor In Radio Frequency Applications

Inventors: Brian Patrick Otis, Nathan Pletcher, Daniel Yeager

Filed May 24, 2013

Granted May 5, 2015

Abstract:

Methods and systems for utilizing oscillator frequency divider settings as a temperature sensor are described herein. An example method may involve a reader device transmitting an RF signal to a tag device that includes an electronic oscillator configured to generate an oscillator signal with an oscillator frequency and a frequency adjuster configured to adjust the oscillator frequency with a frequency adjustment factor to provide a resulting frequency, the oscillator frequency being dependent on a temperature of the tag device and the resulting frequency being based on a reference frequency provided by the RF signal. The method may also involve the reader device receiving data from the tag device, the data being indicative of the oscillator frequency. The method may further involve the reader device determining an estimate of the temperature of the tag device based on at least the received data and a predetermined relationship between temperature and oscillator frequency.

Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device

Inventors: James Etzkorn, Stephen ODriscoll

Filed Jun 14, 2013

Published Dec 18, 2014

Abstract:

Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Physiological Measurement Using Wearable Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published Dec 25, 2014

Abstract:

A wearable device includes a detector configured to detect a response signal transmitted from a portion of subsurface vasculature, the response signal being related to binding of a clinically-relevant analyte to functionalized particles present in a lumen of the subsurface vasculature. Program instructions stored in a computer readable medium of the device, and executable by a processor, may cause the device to determine a concentration of the clinically-relevant analyte based on the response signal detected by the detector; determine whether a medical condition is indicated based on at least the concentration of the clinically-relevant analyte; and, in response to a determination that the medical condition is indicated, transmit data representative of the medical condition via the communication interface. The device may also include a signal source configured to transmit an interrogating signal into the portion of subsurface vasculature, thereby generating a response signal in response to the interrogating signal.

Test Platform for Wrist-Mounted Physiologic Measurement Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published Dec 25, 2014

Abstract:

A test model has an outer polymer layer that models an exterior surface of a human arm and includes at least a wrist portion, an inner polymer core that is at least partially surrounded by the outer polymer layer and extends into the wrist portion, and polymer tubing adjacent to the inner polymer core. The polymer tubing is at least partially surrounded by the outer polymer layer and extends into the wrist portion. The polymer tubing has a first fluid inlet and a first fluid outlet. The test model is substantially free of metallic and magnetic materials.

Physiological Measurement Using Wearable Device

Inventors: Andrew Conrad, Eric Peeters

Filed Jun 21, 2013

Published 20140378777

Dec 25, 2014

Abstract:

A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Container

Inventors: Jeffrey George Linhardt, Daniel Barrows

Filed Jun 24, 2013

Granted Jun 2, 2015

Abstract:

The present disclosure provides an apparatus including a first chamber containing an eye-mountable device. The apparatus may also include a second chamber containing an aqueous solution. The apparatus may also include a membrane positioned between the first chamber and the second chamber. The membrane may be configured to rupture based on application of a force to the apparatus. The ruptured membrane may allow the aqueous solution to engage with the eye-mountable device. The apparatus may also include a lid to seal one or more of the first chamber and the second chamber.

Device Identification

Inventors: Daniel Yeager, Brian Otis, Andrew Nelson

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An eye-mountable device includes a controller embedded in a polymeric material configured for mounting to a surface of an eye. The controller is electrically connected to an antenna included in the eye-mountable device. The controller is configured to: (i) receive an indication of an interrogation signal via the antenna, (ii) responsive to the interrogation signal, output a substantially unique identification sequence; and (iii) use the antenna to communicate the substantially unique identification sequence. The substantially unique identification sequence can then be used by external readers to associate the eye-mountable device with device-specific information without storing such information on the eye-mountable device.

Methods for Adhering a Substrate to a Polymer Layer

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring-shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.

Chemically Reactive Enzyme Immobilization

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains having covalent bonds to an analyte sensing component. The method includes combining the precursor components of the sensing layer, depositing the combined mixture on a surface of an electrode, and curing the deposited mixture.

Porous Polymeric Formulation Prepared Using Monomer

Inventors: Zenghe Liu, Jeffrey George Linhardt

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks.

Porous Polymeric Formulation Prepared Using Porogens

Inventors: Jeffrey George Linhardt, Zenghe Liu, Huanfen Yao

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.

Enzyme Immobilization by Crosslinking

Inventors: Zenghe Liu

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes an electrode, a sensing layer in contact with a surface of the electrode, and a protective membrane. The sensing layer is a crosslinked, hydrophilic copolymer including poly(alkylene oxide) and poly(vinyl pyridine), and an analyte sensing component is immobilized within the crosslinked, hydrophilic copolymer. The protective membrane is a crosslinked, hydrophilic copolymer including alkylene oxide, vinyl pyridine and styrene units. The method involves the formation of a sensing layer on a surface of an electrode, followed by the formation of a protective membrane on a surface of the sensing layer.

Methods for Forming a Channel Through a Polymer Layer Using One or More Photoresist Layers

Inventors: Huanfen Yao, Babak Parviz, Jeffrey George Linhardt

Filed Jun 28, 2013

Granted May 12, 2015

Abstract:

A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to detect an analyte. The method may involve forming a first polymer layer. Further, the method may involve positioning the structure on the first polymer layer. Still further, the method may involve forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer, the second polymer layer, and the one or more photoresist layers. The method may also involve removing the one or more photoresist layers to form a channel through the second polymer layer, wherein the sensor is configured to receive the analyte via the channel.

Devices and Methods for a Contact lens with an Outward Facing Light Source

Inventors: Brian Otis, Robert Francis Wiser, Andrew Nelson

Filed Jun 28, 2013

Granted Sep 16, 2014

Abstract:

A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.

Devices and Methods for a Contact lens with an Inward Facing Light SourceE

Inventors: Brian Otis, William James Biederman

Filed Jun 28, 2013

Published Jan 1, 2015

Abstract:

An eye-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a concave surface and a convex surface, with the concave surface configured to removably mount the eye-mountable device on a corneal surface overlaying a pupil. A light source can be disposed on the substrate and configured to emit light through the concave surface and towards the corneal surface such that the emitted light is viewable through the pupil. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to modulate the light emitted by the light source to provide modulated light.

Reader Communication with Contact Lens Sensors and Display Device

Inventors: Frank Honor, Andrew Nelson, Brian Otis

Filed Jun 28, 2013

Granted Dec 30, 2014

Abstract:

A reader for communicating with both an eye-mountable device and a display device is provided. The reader can transmit radio frequency power to a tag that is part of the eye-mountable device. The reader can communicates with the tag using a first protocol. Communicating with the tag can include having the reader request data from the tag and receive the requested data from the tag. The reader can process the received data. The reader can store the processed data. The reader can communicates with the display device using a second protocol, where the first and second protocols can differ. Communicating with the display device can include having the reader transmit the stored data to the display device. The display device can receive the transmitted data, process the transmitted data, and generate one or more displays including the transmitted and/or processed data.

Using Unique Identifiers to Retrieve Configuration Data for Tag Devices

Inventors: Alice Lin, Andrew Nelson, Daniel Yeager, Brian Otis

Filed Aug 22, 2013

Granted Feb 2, 2016

Abstract:

Methods and systems for using unique identifiers to retrieve configuration data for tag devices are described herein. An example method may involve obtaining a unique identifier associated with a tag device. The tag device may include an antenna and a sensor configured to obtain sensor readings that can be wirelessly transmitted to a reader device via the antenna. The method may also involve determining configuration parameters associated with the tag device based on the unique identifier. The method may further involve storing, in at least one memory, at least a portion of the configuration parameters in association with the unique identifier.

Sacrificial Layers for Bio-Compatible Devices

Inventors: James Etzkorn, Harvey Ho, Huanfen Yao

Filed Aug 27, 2013

Published Mar 5, 2015

Abstract:

A method may involve: forming a sacrificial layer on a working substrate; forming a first bio-compatible layer on the sacrificial layer such that the first bio-compatible layer adheres to the sacrificial layer; forming a conductive pattern on the first bio-compatible layer; mounting an electronic component to the conductive pattern; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, and the conductive pattern; and removing the sacrificial layer to release the bio-compatible device from the working substrate. The first bio-compatible layer defines a first side of a bio-compatible device. The second bio-compatible layer defines a second side of the bio-compatible device.

Nanoparticle Phoresis

Inventors: Andrew Jason Conrad

Filed Sep 5, 2013

Published Mar 5, 2015

Abstract:

Functionalized particles in the blood are able to selectively bind to targets in the blood that have adverse health effects. The binding of the particles to the targets allows the targets to be selectively modified or destroyed by energy from outside the body such that the adverse health effects are reduced or eliminated. The energy is generated by a wearable device which is able to direct the energy into the subsurface vasculature of the wearer of the wearable device. Further, one or more of the functionalized particles may be magnetic, allowing a magnetic field generated by the wearable device and directed into the subsurface vasculature to concentrate the bound targets in a lumen of the subsurface vasculature proximate to the wearable device.

Delivery of Functionalized Particles

Inventors: Andrew Jason Conrad

Filed Sep 5, 2013

Published Mar 5, 2015

Abstract:

A device includes a capsule sized to pass through a lumen of a gastrointestinal tract, a plurality of functionalized particles disposed within the capsule, one or more tissue penetrating members configured to puncture a wall of the lumen of the intestinal tract; and an actuator having a first configuration and a second configuration. The actuator is configured to retain the plurality of functionalized particles within the capsule in the first configuration. The actuator is further configured to advance the plurality of functionalized particles from the capsule into a wall of the lumen of the gastrointestinal tract via the one or more tissue penetrating members by the actuator transitioning from the first configuration to the second configuration. Systems including the device and methods of delivering functionalized particles to the body are also provided.

Assembling Thin Silicon Chips on a Contact Lens

Inventors: James Etzkorn

Filed Sep 12, 2013

Granted Jun 9, 2015

Abstract:

A contact lens having a thin silicon chip integrated therein is provided along with methods for assembling the silicon chip within the contact lens. In an aspect, a method includes creating a plurality of lens contact pads on a lens substrate and creating a plurality of chip contact pads on a chip. The method further involves applying assembly bonding material to the each of the plurality of lens contact pads or chip contact pads, aligning the plurality of lens contact pads with the plurality of chip contact pads, bonding the chip to the lens substrate via the assembly bonding material using flip chip bonding, and forming a contact lens with the lens substrate.

Devices and Methods for a Contact lens with an Outward Facing Light Source

Inventors: Brian Otis, Robert Francis Wiser, Andrew Nelson

Filed Sep 16, 2013

Granted Sep 9, 2014

Abstract:

A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.

Devices and Methods for a Contact lens with an Inward Facing Light Source

Inventors: Brian Otis, William James Biederman

Filed Sep 16, 2013

Granted Jul 1, 2014

Abstract:

An eye-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a concave surface and a convex surface, with the concave surface configured to removably mount the eye-mountable device on a corneal surface overlaying a pupil. A light source can be disposed on the substrate and configured to emit light through the concave surface and towards the corneal surface such that the emitted light is viewable through the pupil. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to modulate the light emitted by the light source to provide modulated light.

Reader Communication With Contact Lens Sensors and Display Device

Inventors: Brian Otis, Frank Honor, Andrew Nelson

Filed Sep 16, 2013

Granted Sep 8, 2015

Abstract:

A reader for communicating with both an eye-mountable device and a display device is provided. The reader can transmit radio frequency power to a tag that is part of the eye-mountable device. The reader can communicates with the tag using a first protocol. Communicating with the tag can include having the reader request data from the tag and receive the requested data from the tag. The reader can process the received data. The reader can store the processed data. The reader can communicates with the display device using a second protocol, where the first and second protocols can differ. Communicating with the display device can include having the reader transmit the stored data to the display device. The display device can receive the transmitted data, process the transmitted data, and generate one or more displays including the transmitted and/or processed data.

Device With Dual Power Sources

Inventors: Nathan Pletcher, Daniel Yeager, William James Biederman, Andrew Nelson

Filed Sep 16, 2013

Granted Jun 3, 2014

Abstract:

A wearable device includes a sensor, auxiliary electronics, a primary power supply configured to harvest radio frequency (RF) radiation received from an external reader and use the harvested RF radiation to power the sensor, and an auxiliary power supply configured to harvest energy other than that received from the external reader and use the harvested energy to supply power to the sensor and/or the auxiliary electronics. The external reader may supply less power in response to operation of the auxiliary power supply. Additionally or alternatively, in response to a determination that the auxiliary power supply is unable to supply power, the wearable device may disable all auxiliary electronics but for the sensor. In response to a determination that the primary power supply is unable to supply power but the auxiliary power supply is able to supply power, the wearable device may retain operating parameters in the memory storage unit using the auxiliary power supply.

Contact Lenses Having Two-Electrode Electrochemical Sensors

Inventors: Zenghe Liu

Filed Sep 17, 2013

Published Jul 10, 2014

Abstract:

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

Contact Lens with Integrated Pulse Oximeter

Inventors: Harvey Ho, Babak Amirparviz

Filed Sep 17, 2013

Granted Dec 9, 2014

Abstract:

Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.

In-vitro Calibration Of An Ophthalmic Analyte Sensor

Inventors: Brian Otis, Zenghe Liu

Filed Sep 19, 2013

Published Apr 17, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.

Encapulated Electronics

Inventors: James Etzkorn, Babak Amirparviz

Filed Sep 19, 2013

Granted Nov 11, 2014

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.

Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement

Inventors: Nathan Pletcher, Brian Otis

Filed Sep 20, 2013

Granted Jan 6, 2015

Abstract:

An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor applies a stabilization voltage between a working electrode and a reference electrode to allow the amperometric current to stabilize before powering measurement electronics configured to measure the amperometric current and communicate the measured amperometric current. The electrochemical sensor consumes less power while applying the stabilization voltage than during the measurement. The measurement is initiated in response to receiving a measurement signal at an antenna in the eye-mountable device.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Sep 20, 2013

Granted Feb 10, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Systems and Methods for Encapsulating Electronics in a Mountable Device

Inventors: James Etzkorn

Filed Sep 23, 2013

Granted Apr 21, 2015

Abstract:

A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern. The sensor electrodes are exposed by removing a portion of the third layer.

Device Having Embedded Antenna

Inventors: James Etzkorn, Stephen ODriscoll

Filed Sep 24, 2013

Published Dec 18, 2014

Abstract:

Body-mountable devices and methods for embedding a structure in a body-mountable device are described. A body-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna. The antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.

Information Processing Method

Inventors: Ehsan Saeedi, Babak Amirparviz

Filed Sep 24, 2013

Published Mar 27, 2014

Abstract:

Systems, apparatus and methods including a contact lens that facilitates collection and/or processing of information associated with sensed features are provided. In one aspect, a system can include a contact lens and an analysis component external to the contact lens. The contact lens can include: a substrate; and a circuit, disposed on or within the substrate. The circuit can include: a plurality of sensors configured to sense respective features associated with a wearer of the contact lens; and a communication component configured to communicate information indicative of sensed features. The analysis component can be configured to: receive the information indicative of the sensed features; and generate statistical information based, at least, on the information indicative of the sensed features.

Container

Inventors: Jeffrey George Linhardt, Daniel Barrows

Filed Sep 24, 2013

Granted Nov 11, 2014

Abstract:

The present disclosure provides an apparatus including a first chamber containing an eye-mountable device. The apparatus may also include a second chamber containing an aqueous solution. The apparatus may also include a membrane positioned between the first chamber and the second chamber. The membrane may be configured to rupture based on application of a force to the apparatus. The ruptured membrane may allow the aqueous solution to engage with the eye-mountable device. The apparatus may also include a lid to seal one or more of the first chamber and the second chamber.

Method And System For Measuring Pyruvate

Inventors: Huanfen Yao, Zenghe Liu

Filed Oct 17, 2013

Granted Aug 4, 2015

Abstract:

A body-mountable pyruvate sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with pyruvate. Application of a voltage between the working electrode and the reference electrode causes a current related to a concentration of pyruvate in a fluid to which the electrochemical sensor is exposed; the current is measured by the body-mountable device and wirelessly communicated.

Method And System For Measuring Urea

Inventors: Huanfen Yao, Zenghe Liu

Filed Oct 17, 2013

Published Apr 23, 2015

Abstract:

A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.

Modulation of a Response Signal to Distinguish Between Analyte and Background Signals

Inventors: Jason Thompson, Andrew Conrad, Eric Peeters, Vikram Singh Bajaj, Mark Askew

Filed Oct 23, 2013

Published Apr 23, 2015

Abstract:

A method for modulating a response signal includes introducing functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles are configured to interact with one or more target analytes present in blood circulating in the subsurface vasculature; and non-invasively detecting the one or more target analytes. A response signal, which may include a background signal and an analyte response signal related to interaction of the functionalized particles with the one or more target analytes, is transmitted from the subsurface vasculature. A modulation configured to alter the response signal such that the analyte response signal is affected differently than the background signal may be applied to a portion of subsurface vasculature. Analyte detection may be achieved by differentiating the analyte response signal from the background.
19 Avr 2016
Admin · 14 vistas · Escribir un comentario

Página precedente  1, 2, 3, 4, 5, 6, 7, 8  Página siguiente